Abstract
Dyslipidemia is considered to be one of the main heart risk factors, affecting the endothelial vascular function, which can be non-invasively investigated by ultrasound flow-mediated dilation (US-FMD). However, US-FMD comes at a high-cost and is operator-dependent. In this paper, the effect of dyslipidemia on the photoplethysmogram (PPG) signal recorded from collateral index fingers is investigated following a previous study where it was shown that results similar to that of US-FMD can be replicated by the PPG. Two groups, consisting of 30 healthy subjects free from any risk factors and 30 subjects who have only dyslipidemia as risk factor were respectively considered. The percent change in the AC (peak-to-peak) values versus time of the PPG after flow release following 4 min of brachial artery blockage (reactive hyperemia) was obtained (PPG-FMD). Results indicate that a very simple morphological feature allows for a significant (p < 0. 00001) discrimination between the control and pathologic groups.
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References
Celermajer, D.S.: Endothelial dysfunction: Does it matter? Is it reversible. J. Am. Coll. Cardiol. 30(2):325–33 (August 1997)
Verma, S., Anderson, T.J.: Fundamentals of endothelial function for the clinical cardiologist. J. Am. Heart Assoc. Circulat. 105:546–549 (2002)
Meyer, B., Mörtl, D., Strecker, K., Hülsmann, M., Kulemann, V., Neunteufl, T., Pacher, R., Berger, R.: Flow-mediated vasodilation predicts outcome in patients with chronic heart failure. J. Am. Coll. Cardiol. 46(6):1011–1018 (2005)
Anderson, E.A., Mark, A.L.: Flow-mediated and reflex changes in large peripheral artery tone in humans. J. Am. Heart Assoc. Circulat. 79:93–100 (1989)
Corretti, M.C., Anderson, T.J., Benjamin, E.J., Celermajer, D., Charbonneau, F., Creager, M.A., Deanfield, J., Drexler, H., Gerhard- Herman, M., Herrington, D.: Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery – a report of the international brachial artery reactivity task force. J. Am. Coll. Cardiol. 39: 257–265 (2002)
Su, W., Cheng, S., Hsu, T., Ho, W.: Abnormal flow-mediated vasodilation in normal-tension glaucoma using a noninvasive determination for peripheral. Invest. Ophthalmol. Visual Sci. 47(8):3390–3394 (August 2006)
Kao, Y.H., Mohler, E.R., Arger, P.H., Sehgal, C.M.: Brachial artery: measurement of flow-mediated dilation with cross sectional US-technical validation. J. Radiol. 228(3):895–900 (2003)
Leeson, P., Thorne, S., Donald, A., Mullen, M., Clarkson, P., Deanfield, J.: Non-invasive measurement of endothelial function: effect on brachial artery dilatation of graded endothelial. J. Heart 78:22–27 (1997)
Zahedi, E., Jaafar, R., Mohd Ali, M.A., Mohamed, A.L., Maskon, O.: Finger photoplethysmogram pulse amplitude changes induced by flow mediated dilation. Physiol. Measure. 29(5):625–637 (2008)
Allen, J.: Photoplethysmography and its application in clinical physiological measurement. J. Physiol. Measure. 28:1–39 (2007)
Crabtree, V.P., Smith, P.R.: Physiological models of the human vasculature and photoplethysmography. Electron. Syst. Con. Division Res. (2003)
Zaheditochai, M., Jaafar, R., Zahedi, E.: Non-invasive techniques for assessing the endothelial dysfunction: ultrasound versus photoplethysmography. Proceedings of International Conference of Biomedical Engineering 23:65–68 (2009)
Allen, J., Oates, C.P., Lees, T.A., Murray, A.: Photoplethysmography detection of lower limb peripheral arterial occlusive disease: a comparison of pulse timing, amplitude and shape characteristics. J. Physiol. Measure. 26:811–821 (2005)
Zaheditochai, M., Zahedi, E., Mohd Ali, M.A.: Effect of dyslipidemia on photoplethysmography flow mediated dilation. World Congress Engineering, pp. 1881–1884 (2009)
Acknowledgement
The authors would like to thank Universiti Kebangsaan Malaysia for supporting this work under the University Research Grant UKM-AP-TKP-07–2009.
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Zaheditochai, M., Zahedi, E., Ali, M.A.M. (2010). Effect of Dyslipidemia on a Simple Morphological Feature Extracted from Photoplethysmography Flow Mediated Dilation. In: Ao, SI., Gelman, L. (eds) Electronic Engineering and Computing Technology. Lecture Notes in Electrical Engineering, vol 60. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8776-8_47
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DOI: https://doi.org/10.1007/978-90-481-8776-8_47
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